PBI-4050 Improves Metabolic Regulation and Diabetic Nephropathy through Reduction of ER Stress, Pro-Inflammatory/Fibrotic Markers, Galectin-

June 22, 2018

What Does this Study Demonstrate?

This study demonstrates that PBI-4050:

  • Improves triglyceride and glucose metabolism
  • Reduces collagen and galectin-3 deposition in WAT and kidney
  • Reduces ER stress and pro-inflammatory/fibrotic markers in kidney

These results suggest that PBI-4050 is a strong potential candidate for the treatment of metabolic diseases and related diabetic nephropathy.

 

 

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PBI-4050 decreases adenine-induced tubulointerstitial injury and er-stress; implications of the GPR40 receptor
PBI-4050 decreases adenine-induced tubulointerstitial injury and er-stress; implications of the GPR40 receptor

The aim of this study was to further examine the effects of PBI-4050 in both WT and GPR40 activation-/- mic...

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